New anti-SARS-CoV-2 aminoadamantane compounds as antiviral candidates for the treatment of COVID-19
Here, the antiviral activity of aminoadamantane derivatives were evaluated against SARS-CoV-2. The compounds exhibited low cytotoxicity to Vero, HEK293 and CALU-3 cells up to a concentration of 1,000 µM. The inhibitory concentration (IC50) of aminoadamantane was 39.71 µM in Vero CCL-81 cells and the...
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Bibliographic Details
| Main Authors: |
Daisymara Priscila de Almeida Marques,
Luis Adan Flores Andrade,
Erik Vinicius Sousa Reis,
Felipe Alves Clarindo,
Thaís de Fátima Silva Moraes,
Karine Lima Lourenço,
Wellington Alves De Barros,
Nathália Evelyn Morais Costa,
Lídia Maria de Andrade,
Ágata Lopes-Ribeiro,
Mariella Sousa Coêlho Maciel,
Laura Cardoso Corrêa-Dias,
Isabela Neves de Almeida,
Thalita Souza Arantes,
Vivian Costa Vasconcelos Litwinski,
Leonardo Camilo de Oliveira,
Mateus Sá Magalhães Serafim,
Vinicius Gonçalves Maltarollo,
Silvia Carolina Guatimosim,
Mário Morais Silva,
Moriya Tsuji,
Rafaela Salgado Ferreira,
Luiza Valença Barreto,
Edel Figueiredo Barbosa-Stancioli,
Flávio Guimarães da Fonseca,
Ângelo De Fátima,
Jordana Grazziela Alves Coelho-dos-Reis |
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| Format: | Article
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| Language: | English |
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| Published: |
Elsevier
2024-02-01
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| Series: | Virus Research
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| Subjects: | |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0168170223002538
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