Redox integration of signaling and metabolism in a head and neck cancer model of radiation resistance using COSMRO

Redox integration of signaling and metabolism in a head and neck cancer model of radiation resistance using COSMRO

Redox metabolism is increasingly investigated in cancer as driving regulator of tumor progression, response to therapies and long-term patients’ quality of life. Well-established cancer therapies, such as radiotherapy, either directly impact redox metabolism or have redox-dependent mechanisms of act...

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Bibliographic Details
Main Authors: Zhiwei Ji, Jade Moore, Nelmi O. Devarie-Baez, Joshua Lewis, Hanzhi Wu, Kirtikar Shukla, Elsa I. Silva Lopez, Victor Vitvitsky, Chia-Chi Chuang Key, Mercedes Porosnicu, Melissa L. Kemp, Ruma Banerjee, John S. Parks, Allen W. Tsang, Xiaobo Zhou, Cristina M. Furdui
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-01-01
Series:Frontiers in Oncology
Subjects:
redox metabolism
head and neck cancer
mixed integer programming
flux balance analysis
cholesterol metabolism
steroidogenesis, radiation response
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.946320/full

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https://www.frontiersin.org/articles/10.3389/fonc.2022.946320/full

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