B Cell-Intrinsic Role for IRF5 in TLR9/BCR-Induced Human B Cell Activation, Proliferation, and Plasmablast Differentiation

B Cell-Intrinsic Role for IRF5 in TLR9/BCR-Induced Human B Cell Activation, Proliferation, and Plasmablast Differentiation

Upon recognition of antigen, B cells undergo rapid proliferation followed by differentiation to specialized antibody secreting cells (ASCs). During this transition, B cells are reliant upon a multilayer transcription factor network to achieve a dramatic remodeling of the B cell transcriptional lands...

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Bibliographic Details
Main Authors: Saurav De, Baohong Zhang, Tiffany Shih, Sukhwinder Singh, Aaron Winkler, Robert Donnelly, Betsy J. Barnes
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-01-01
Series:Frontiers in Immunology
Subjects:
interferon regulatory factor 5
human primary B cells
plasmablasts
autoantibodies
immunoglobulin G
differentiation
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.01938/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2017.01938/full

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