MIRTH: Metabolite Imputation via Rank-Transformation and Harmonization

MIRTH: Metabolite Imputation via Rank-Transformation and Harmonization

Abstract Out of the thousands of metabolites in a given specimen, most metabolomics experiments measure only hundreds, with poor overlap across experimental platforms. Here, we describe Metabolite Imputation via Rank-Transformation and Harmonization (MIRTH), a method to impute unmeasured metabolite...

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Bibliographic Details
Main Authors: Benjamin A. Freeman, Sophie Jaro, Tricia Park, Sam Keene, Wesley Tansey, Ed Reznik
Format: Article
Language:English
Published: BMC 2022-09-01
Series:Genome Biology
Subjects:
Metabolomics
Missing data
Imputation
Unmeasured metabolites
Matrix factorization
Online Access:https://doi.org/10.1186/s13059-022-02738-3

Internet

https://doi.org/10.1186/s13059-022-02738-3

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