Differential Oxygen Exposure Modulates Mesenchymal Stem Cell Metabolism and Proliferation through mTOR Signaling

Differential Oxygen Exposure Modulates Mesenchymal Stem Cell Metabolism and Proliferation through mTOR Signaling

Mesenchymal stem cells reside under precise hypoxic conditions that are paramount in determining cell fate and behavior (metabolism, proliferation, differentiation, etc.). In this work, we show that different oxygen tensions promote a distinct proliferative response and affect the biosynthetic deman...

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Bibliographic Details
Main Authors: Inês Moniz, João Ramalho-Santos, Ana F. Branco
Format: Article
Language:English
Published: MDPI AG 2022-03-01
Series:International Journal of Molecular Sciences
Subjects:
mesenchymal stem cells
hypoxia
metabolism
mTOR
cobalt chloride
Online Access:https://www.mdpi.com/1422-0067/23/7/3749

Internet

https://www.mdpi.com/1422-0067/23/7/3749

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