Pyridinecarboxylic Acid Derivative Stimulates Pro-Angiogenic Mediators by PI3K/AKT/mTOR and Inhibits Reactive Nitrogen and Oxygen Species and NF-κB Activation Through a PPARγ-Dependent Pathway in T. cruzi-Infected Macrophages

Pyridinecarboxylic Acid Derivative Stimulates Pro-Angiogenic Mediators by PI3K/AKT/mTOR and Inhibits Reactive Nitrogen and Oxygen Species and NF-κB Activation Through a PPARγ-Dependent Pathway in T. cruzi-Infected Macrophages

Chagas disease is caused by Trypanosoma cruzi infection and represents an important public health concern in Latin America. Macrophages are one of the main infiltrating leukocytes in response to infection. Parasite persistence could trigger a sustained activation of these cells, contributing to the...

Full description

Bibliographic Details
Main Authors: Federico Nicolás Penas, Davide Carta, Ágata Carolina Cevey, María Jimena Rada, Azul Victoria Pieralisi, María Grazia Ferlin, María Elena Sales, Gerardo A. Mirkin, Nora Beatriz Goren
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-01-01
Series:Frontiers in Immunology
Subjects:
new PPARγ ligand
PI3K/AKT/mTOR
NF-κB pathway
Trypanosoma cruzi
macrophages
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.02955/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.02955/full

Similar Items