Targeting soluble amyloid-beta oligomers with a novel nanobody

Targeting soluble amyloid-beta oligomers with a novel nanobody

Abstract The classical amyloid cascade hypothesis postulates that the aggregation of amyloid plaques and the accumulation of intracellular hyperphosphorylated Tau tangles, together, lead to profound neuronal death. However, emerging research has demonstrated that soluble amyloid-β oligomers (SAβOs)...

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Bibliographic Details
Main Authors: Justin R. Haynes, Clayton A. Whitmore, William J. Behof, Charlotte A. Landman, Henry H. Ong, Andrew P. Feld, Isabelle C. Suero, Celeste B. Greer, John C. Gore, Printha Wijesinghe, Joanne A. Matsubara, Brian E. Wadzinski, Benjamin W. Spiller, Wellington Pham
Format: Article
Language:English
Published: Nature Portfolio 2024-07-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-024-66970-6

Internet

https://doi.org/10.1038/s41598-024-66970-6

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