Assessments of the In Vitro and In Vivo Linker Stability and Catabolic Fate for the Ortho Hydroxy-Protected Aryl Sulfate Linker by Immuno-Affinity Capture Liquid Chromatography Quadrupole Time-of-Flight Mass Spectrometric Assay

Assessments of the In Vitro and In Vivo Linker Stability and Catabolic Fate for the Ortho Hydroxy-Protected Aryl Sulfate Linker by Immuno-Affinity Capture Liquid Chromatography Quadrupole Time-of-Flight Mass Spectrometric Assay

Antibody–drug conjugate (ADC) linkers play an important role in determining the safety and efficacy of ADC. The Ortho Hydroxy-Protected Aryl Sulfate (OHPAS) linker is a newly developed linker in the form of a di-aryl sulfate structure consisting of phenolic payload and self-immolative group (SIG). I...

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Bibliographic Details
Main Authors: Byeong ill Lee, Seo-jin Park, Yuri Park, Seok-Ho Shin, Jang-mi Choi, Min-jae Park, Jeong-hyeon Lim, Sun Young Kim, Hyangsook Lee, Young G. Shin
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:Pharmaceutics
Subjects:
antibody–drug conjugate
LC-qTOF-MS
OHPAS linker
VC-PABC linker
linker stability
catabolic fate
Online Access:https://www.mdpi.com/1999-4923/13/1/125

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https://www.mdpi.com/1999-4923/13/1/125

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