Neuregulin-1 promotes functional improvement by enhancing collateral sprouting in SOD1G93A ALS mice and after partial muscle denervation

Neuregulin-1 promotes functional improvement by enhancing collateral sprouting in SOD1G93A ALS mice and after partial muscle denervation

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by progressive degeneration of motoneurons, which is preceded by loss of neuromuscular connections in a “dying back” process. Neuregulin-1 (Nrg1) is a neurotrophic factor essential for the development and maintenance of...

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Bibliographic Details
Main Authors: Renzo Mancuso, Anna Martínez-Muriana, Tatiana Leiva, David Gregorio, Lorena Ariza, Marta Morell, Jesús Esteban-Pérez, Alberto García-Redondo, Ana C. Calvo, Gabriela Atencia-Cibreiro, Gabriel Corfas, Rosario Osta, Assumpció Bosch, Xavier Navarro
Format: Article
Language:English
Published: Elsevier 2016-11-01
Series:Neurobiology of Disease
Subjects:
Neuregulin-1
Amyotrophic lateral sclerosis
Neuromuscular junction
Motoneuron
Collateral sprouting
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996116301814

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http://www.sciencedirect.com/science/article/pii/S0969996116301814

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