Pin1 colocalization with phosphorylated tau in Alzheimer's disease and other tauopathies

Pin1 colocalization with phosphorylated tau in Alzheimer's disease and other tauopathies

Pin1, a peptidyl-prolyl isomerase binds to mitotic serine or threonine phosphoproteins. In Alzheimer's disease (AD) evidence points to the reactivation of mitosis in vulnerable neurons. Tangles composed of hyperphosphorylated tau contain phosphorylated Thr231 (pThr231 tau), which occurs to a gr...

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Bibliographic Details
Main Authors: Pankajavalli Ramakrishnan, Dennis W Dickson, Peter Davies
Format: Article
Language:English
Published: Elsevier 2003-11-01
Series:Neurobiology of Disease
Subjects:
Alzheimer's disease
Neurodegeneration
Pin1
Tau
Tauopathies
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996103001098

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http://www.sciencedirect.com/science/article/pii/S0969996103001098

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