Rational Design and Synthesis of Altered Peptide Ligands based on Human Myelin Oligodendrocyte Glycoprotein 35–55 Epitope: Inhibition of Chronic Experimental Autoimmune Encephalomyelitis in Mice

Rational Design and Synthesis of Altered Peptide Ligands based on Human Myelin Oligodendrocyte Glycoprotein 35–55 Epitope: Inhibition of Chronic Experimental Autoimmune Encephalomyelitis in Mice

Experimental autoimmune encephalomyelitis (EAE) is a demyelinating disease of the central nervous system and is an animal model of multiple sclerosis (MS). Although the etiology of MS remains unclear, there is evidence T-cell recognition of immunodominant epitopes of myelin proteins, such as the 35–...

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Bibliographic Details
Main Authors: Theodore Tselios, Mihalis Aggelidakis, Anthi Tapeinou, Vivian Tseveleki, Ioannis Kanistras, Dimitrios Gatos, John Matsoukas
Format: Article
Language:English
Published: MDPI AG 2014-11-01
Series:Molecules
Subjects:
multiple sclerosis
experimental autoimmune encephalomyelitis
altered peptide ligand
cyclic peptides
Online Access:http://www.mdpi.com/1420-3049/19/11/17968

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http://www.mdpi.com/1420-3049/19/11/17968

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