Azithromycin attenuates Pseudomonas-induced lung inflammation by targeting bacterial proteins secreted in the cultured medium

Azithromycin attenuates Pseudomonas-induced lung inflammation by targeting bacterial proteins secreted in the cultured medium

Background: Pseudomonas aeruginosa airway infections are a major cause of morbidity and mortality in patients with Cystic Fibrosis (CF). Azithromycin improves the related clinical outcomes but its mechanisms of action remain poorly understood. We tested the hypothesis that azithromycin down-regulate...

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Bibliographic Details
Main Authors: Teresinha Leal, Gabriella Bergamini, François Huaux, Nadtha Panin, Sabrina Noel, Barbara Dhooghe, Jérémy Boris Haaf, Pierluigi Mauri, Sara Motta, Dario Di Silvestre, Paola Melotti, Claudio Sorio
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-11-01
Series:Frontiers in Immunology
Subjects:
Azithromycin
Cystic Fibrosis
Cytokines
Inflammation
Proteomics
Pseudomonas aeruginosa
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2016.00499/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fimmu.2016.00499/full

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