Alteration of AP-endonuclease1 expression in curcumin-treated fibrotic rats

Alteration of AP-endonuclease1 expression in curcumin-treated fibrotic rats

Background. Apurinic/apyrimidinic endonuclease1/ redox factor-1 (APE1/Ref-1) is a multifunctional protein involved in DNA base excision repair and redox regulation of many transcription factors. It is an important pro-survival protein activated in response to oxidative stress. Increased level of thi...

Full description

Bibliographic Details
Main Authors:	Ahmad R. Bassiouny, Amira Zaky, Faten Fawky, Kamal M. Kandeel
Format:	Article
Language:	English
Published:	Elsevier 2011-10-01
Series:	Annals of Hepatology
Subjects:	Apurinic/apyrimidinic endonuclease 1 Hepatic stellate cells Curcumin Tumor necrosis factor-α (TNF-α) Nuclear factor-kappaB (Nf-κB) Transforming growth factor-β (TGF-β)
Online Access:	http://www.sciencedirect.com/science/article/pii/S1665268119315212

Similar Items

The Kinetic Mechanism of 3′-5′ Exonucleolytic Activity of AP Endonuclease Nfo from <i>E. coli</i>
by: Svetlana I. Senchurova, et al.
Published: (2022-09-01)

The role of genotype/phenotype at apurinic/apyrimidinic endonuclease Rs1130409 in renal cell carcinoma
by: Cheng-Hsi Liao, et al.
Published: (2020-01-01)

Elevated Plasma Apurinic/Apyrimidinic Endonuclease 1/Redox Effector Factor-1 Levels in Refractory Kawasaki Disease
by: Yu-Ran Lee, et al.
Published: (2022-01-01)

α1-Adrenoceptor agonist methoxamine inhibits base excision repair via inhibition of apurinic/apyrimidinic endonuclease 1 (APE1)
by: Kohutova Aneta, et al.
Published: (2023-06-01)

Chemical Inhibition of Apurinic-Apyrimidinic Endonuclease 1 Redox and DNA Repair Functions Affects the Inflammatory Response via Different but Overlapping Mechanisms
by: Thais Teixeira Oliveira, et al.
Published: (2021-09-01)

Comparative Analysis of Exo- and Endonuclease Activities of APE1-like Enzymes
by: Anastasiia T. Davletgildeeva, et al.
Published: (2022-03-01)

Expression of tumor necrosis factor-α and nuclear factor-kappaB/RelA and the pathogenesis of psoriasis
by: Nikhil Moorchung, et al.
Published: (2014-01-01)

Elevated APE1/Ref-1 Levels of Synovial Fluids in Patients with Rheumatoid Arthritis: Reflection of Disease Activity
by: In Seol Yoo, et al.
Published: (2021-11-01)

17<i>β</i>-Estradiol Increases APE1/Ref-1 Secretion in Vascular Endothelial Cells and Ovariectomized Mice: Involvement of Calcium-Dependent Exosome Pathway
by: Yu-Ran Lee, et al.
Published: (2021-08-01)

Diagnostic value and significance of serum APE1 in colorectal cancer
by: YANG Yuxin, et al.
Published: (2020-01-01)

Inhibition of APE1/Ref-1 for Neovascular Eye Diseases: From Biology to Therapy
by: Gabriella D. Hartman, et al.
Published: (2021-09-01)

The DNA Repair Enzyme Apurinic/Apyrimidinic Endonuclease (Apex Nuclease) 2 Has the Potential to Protect against Down-Regulation of Chondrocyte Activity in Osteoarthritis
by: Naoko Yui, et al.
Published: (2014-08-01)

Common Kinetic Mechanism of Abasic Site Recognition by Structurally Different Apurinic/Apyrimidinic Endonucleases
by: Alexandra A. Kuznetsova, et al.
Published: (2021-08-01)

The regulatory role of APE1 in epithelial‐to‐mesenchymal transition and in determining EGFR‐TKI responsiveness in non‐small‐cell lung cancer
by: Xiao Yang, et al.
Published: (2018-09-01)

Cleavage of the APE1 N-Terminal Domain in Acute Myeloid Leukemia Cells Is Associated with Proteasomal Activity
by: Lisa Lirussi, et al.
Published: (2020-03-01)

The Role of Active-Site Plasticity in Damaged-Nucleotide Recognition by Human Apurinic/Apyrimidinic Endonuclease APE1
by: Anatoly A. Bulygin, et al.
Published: (2020-08-01)

Apurinic/apyrimidinic endonuclease 1 performs multiple roles in controlling the outcome of cancer cells toward radiation and chemotherapeutic agents
by: Dindial Ramotar, et al.
Published: (2018-01-01)

Molecular Mechanisms Regulating the DNA Repair Protein APE1: A Focus on Its Flexible N-Terminal Tail Domain
by: David J. López, et al.
Published: (2021-06-01)

Inner Amino Acid Contacts Are Key Factors of Multistage Structural Rearrangements of DNA and Affect Substrate Specificity of Apurinic/Apyrimidinic Endonuclease APE1
by: Anatoly A. Bulygin, et al.
Published: (2023-07-01)

Protective effect of secretory APE1/Ref‐1 on doxorubicin‐induced cardiotoxicity via suppression of ROS and p53 pathway
by: Soo Yeon An, et al.
Published: (2024-04-01)

Impact of the APE1 Redox Function Inhibitor E3330 in Non-Small Cell Lung Cancer Cells Exposed to Cisplatin: Increased Cytotoxicity and Impairment of Cell Migration and Invasion
by: Rita Manguinhas, et al.
Published: (2020-06-01)

The Enigma of Substrate Recognition and Catalytic Efficiency of APE1-Like Enzymes
by: Anastasiia T. Davletgildeeva, et al.
Published: (2021-03-01)

The linkage between mercury-caused neuro- and genotoxicity via the inhibition of DNA repair machinery: fish brain model
by: V.S. Nedzvetsky, et al.
Published: (2022-03-01)

Inflammatory response in a rat model of gastroschisis is associated with an increase of NF-kappaB
by: L. Sbragia, et al.
Published: (2010-02-01)

Gypenosides attenuate lipopolysaccharide-induced neuroinflammation and anxiety-like behaviors in rats
by: Bombi Lee, et al.
Published: (2018-09-01)

Emodin ameliorates lipopolysaccharides-induced corneal inflammation in rats
by: Guo-Ling Chen, et al.
Published: (2015-08-01)

Study progress of the correlation between peri⁃implantitis，IL⁃1β，TNF⁃α and NF⁃κB signal transduction
by: CHEN Yuxiong, et al.
Published: (2018-10-01)

Eruberin A, a Natural Flavanol Glycoside, Exerts Anti-Fibrotic Action on Pancreatic Stellate Cells
by: Siu Wai Tsang, et al.
Published: (2015-07-01)

A DNA/RNA hybrid fluorescent probe for high-throughput quantification of the activity of human apurinic/apyrimidinic endonuclease 1 in subcellular extracts
by: Peng Lu, et al.
Published: (2023-09-01)

Insights into Mechanisms of Damage Recognition and Catalysis by APE1-like Enzymes
by: Anatoly A. Bulygin, et al.
Published: (2022-04-01)

Human Dental Pulp Stem Cells via the NF-κB Pathway
by: Shensheng Gu, et al.
Published: (2015-07-01)

Antiinflammatory and Antiphotodamaging Effects of Ergostatrien-3β-ol, Isolated from Antrodia camphorata, on Hairless Mouse Skin
by: Yueh-Hsiung Kuo, et al.
Published: (2016-09-01)

Apurinic/Apyrimidinic Endonuclease 1 and Tyrosyl-DNA Phosphodiesterase 1 Prevent Suicidal Covalent DNA-Protein Crosslink at Apurinic/Apyrimidinic Site
by: Natalia A. Lebedeva, et al.
Published: (2021-01-01)

Factores de crecimiento III: factores transformadores del crecimiento (TGF) Growth factors III part: transforming growth factors (TGF)
by: Hilda Norha Jaramillo Londoño, et al.
Published: (1996-04-01)

The Impact of Human DNA Glycosylases on the Activity of DNA Polymerase β toward Various Base Excision Repair Intermediates
by: Artemiy S. Bakman, et al.
Published: (2023-05-01)

APE1/Ref-1 as a Therapeutic Target for Inflammatory Bowel Disease
by: Lauren Sahakian, et al.
Published: (2023-10-01)

Role of Inflammation and Oxidative Stress Mediators in Gliomas
by: Alfredo Conti, et al.
Published: (2010-04-01)

Regulation of the NF-κB-mediated transcription of inflammatory genes
by: Dev eBhatt, et al.
Published: (2014-02-01)

NF-κB in Cancer Immunity: Friend or Foe?
by: Guilhem Lalle, et al.
Published: (2021-02-01)

RTA Occupancy of the Origin of Lytic Replication during Murine Gammaherpesvirus 68 Reactivation from B Cell Latency
by: Alexis L. Santana, et al.
Published: (2017-02-01)