Enhancing CDC and ADCC of CD19 Antibodies by Combining Fc Protein-Engineering with Fc Glyco-Engineering

Enhancing CDC and ADCC of CD19 Antibodies by Combining Fc Protein-Engineering with Fc Glyco-Engineering

Background: Native cluster of differentiation (CD) 19 targeting antibodies are poorly effective in triggering antibody-dependent cell-mediated cytotoxicity (ADCC) and complement-dependent cytotoxicity (CDC), which are crucial effector functions of therapeutic antibodies in cancer immunotherapy. Both...

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Bibliographic Details
Main Authors: Sophia Roßkopf, Klara Marie Eichholz, Dorothee Winterberg, Katarina Julia Diemer, Sebastian Lutz, Ira Alexandra Münnich, Katja Klausz, Thies Rösner, Thomas Valerius, Denis Martin Schewe, Andreas Humpe, Martin Gramatzki, Matthias Peipp, Christian Kellner
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:Antibodies
Subjects:
antibody therapy
cluster of differentiation 19 (CD19)
CD19
Fc fragment crystallizable (Fc)
Fc engineering
complement-dependent cytotoxicity (CDC)
Online Access:https://www.mdpi.com/2073-4468/9/4/63

Internet

https://www.mdpi.com/2073-4468/9/4/63

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