In silico mutagenesis-based designing of oncogenic SHP2 peptide to inhibit cancer progression

Abstract Cancer is among the top causes of death, accounting for an estimated 9.6 million deaths in 2018, it appeared that approximately 500,000 people die from cancer in the United States alone annually. The SHP2 plays a major role in regulation of cell growth, proliferation, and differentiation, a...

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Bibliographic Details
Main Authors: Muhammad Shahab, Shahin Shah Khan, Maryam Zulfat, Yousef A. Bin Jardan, Amare Bitew Mekonnen, Mohammed Bourhia, Guojun Zheng
Format: Article
Language:English
Published: Nature Portfolio 2023-06-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-023-37020-4