Sirt3 Protects Against Thoracic Aortic Dissection Formation by Reducing Reactive Oxygen Species, Vascular Inflammation, and Apoptosis of Smooth Muscle Cells

Sirt3 Protects Against Thoracic Aortic Dissection Formation by Reducing Reactive Oxygen Species, Vascular Inflammation, and Apoptosis of Smooth Muscle Cells

Sirtuin3 (Sirt3) is a histone deacetylase involved in the regulation of many cellular processes. Sirt3 deficiency is known to increase oxidative stress. Reactive oxygen species (ROS) promote degradation of the extracellular matrix and vascular smooth muscle cell (VSMC) apoptosis. Reducing oxidative...

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Bibliographic Details
Main Authors: Lin Qiu, Shaolei Yi, Tingting Yu, Yan Hao
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Cardiovascular Medicine
Subjects:
aortic dissection
sirt3
SMC
inflammation
apoptosis
Online Access:https://www.frontiersin.org/articles/10.3389/fcvm.2021.675647/full

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https://www.frontiersin.org/articles/10.3389/fcvm.2021.675647/full

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