TAT-mediated transduction of MafA protein in utero results in enhanced pancreatic insulin expression and changes in islet morphology.

TAT-mediated transduction of MafA protein in utero results in enhanced pancreatic insulin expression and changes in islet morphology.

Alongside Pdx1 and Beta2/NeuroD, the transcription factor MafA has been shown to be instrumental in the maintenance of the beta cell phenotype. Indeed, a combination of MafA, Pdx1 and Ngn3 (an upstream regulator of Beta2/NeuroD) was recently reported to lead to the effective reprogramming of acinar...

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Bibliographic Details
Main Authors: Nancy Vargas, Silvia Álvarez-Cubela, Jaime A Giraldo, Margarita Nieto, Nicholas M Fort, Sirlene Cechin, Enrique García, Pedro Espino-Grosso, Christopher A Fraker, Camillo Ricordi, Luca Inverardi, Ricardo L Pastori, Juan Domínguez-Bendala
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3150355?pdf=render

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http://europepmc.org/articles/PMC3150355?pdf=render

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