Induction of Liver Size Reduction in Zebrafish Larvae by the Emerging Synthetic Cannabinoid 4F-MDMB-BINACA and Its Impact on Drug Metabolism

Induction of Liver Size Reduction in Zebrafish Larvae by the Emerging Synthetic Cannabinoid 4F-MDMB-BINACA and Its Impact on Drug Metabolism

Zebrafish (ZF; <i>Danio rerio</i>) larvae have become a popular in vivo model in drug metabolism studies. Here, we investigated the metabolism of methyl 2-[1-(4-fluorobutyl)-1<i>H</i>-indazole-3-carboxamido]-3,3-dimethylbutanoate (4F-MDMB-BINACA) in ZF larvae after direct adm...

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Bibliographic Details
Main Authors: Yu Mi Park, Charlotte Dahlem, Markus R. Meyer, Alexandra K. Kiemer, Rolf Müller, Jennifer Herrmann
Format: Article
Language:English
Published: MDPI AG 2022-02-01
Series:Molecules
Subjects:
zebrafish larvae model
drug metabolism
cannabinoid receptors (CB1 and CB2)
mass spectrometry imaging (MSI)
hepatotoxicity
microinjection
Online Access:https://www.mdpi.com/1420-3049/27/4/1290

Internet

https://www.mdpi.com/1420-3049/27/4/1290

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