Activation-Free Sulfonyl Fluoride Probes for Fragment Screening

Activation-Free Sulfonyl Fluoride Probes for Fragment Screening

SuFEx chemistry is based on the unique reactivity of the sulfonyl fluoride group with a range of nucleophiles. Accordingly, sulfonyl fluorides label multiple nucleophilic amino acid residues, making these reagents popular in both chemical biology and medicinal chemistry applications. The reactivity...

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Bibliographic Details
Main Authors: László Petri, Péter Ábrányi-Balogh, Noémi Csorba, Aaron Keeley, József Simon, Ivan Ranđelović, József Tóvári, Gitta Schlosser, Dániel Szabó, László Drahos, György M. Keserű
Format: Article
Language:English
Published: MDPI AG 2023-03-01
Series:Molecules
Subjects:
chemical probe
covalent fragment
electrophilic warhead
fragment screening
sulfonyl fluoride
targeted covalent inhibitor
Online Access:https://www.mdpi.com/1420-3049/28/7/3042

Internet

https://www.mdpi.com/1420-3049/28/7/3042

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