The Role of Autophagy and Pyroptosis in Liver Disorders

The Role of Autophagy and Pyroptosis in Liver Disorders

Pyroptosis is a programmed cell death caused by inflammasomes, which can detect cell cytosolic contamination or disturbance. In pyroptosis, caspase-1 or caspase-11/4/5 is activated, cleaving gasdermin D to separate its N-terminal pore-forming domain (PFD). The oligomerization of PFD forms macropores...

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Bibliographic Details
Main Authors: Huijie Zhao, Huiyang Liu, Yihan Yang, Honggang Wang
Format: Article
Language:English
Published: MDPI AG 2022-06-01
Series:International Journal of Molecular Sciences
Subjects:
autophagy
pyroptosis
non-alcoholic fatty liver disease
hepatocellular carcinoma
hepatotoxicity
Online Access:https://www.mdpi.com/1422-0067/23/11/6208

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https://www.mdpi.com/1422-0067/23/11/6208

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