Interaction of Hoechst 33342 with POPC Membranes at Different pH Values

Interaction of Hoechst 33342 with POPC Membranes at Different pH Values

Hoechst 33342 (H33342) is a fluorescent probe that is commonly used to stain the DNA of living cells. To do so, it needs to interact with and permeate through cell membranes, despite its high overall charge at physiological pH values. In this work, we address the effect of pH in the association of H...

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Bibliographic Details
Main Authors: Margarida M. Cordeiro, Hugo A. L. Filipe, Patrícia dos Santos, Jaime Samelo, João P. Prates Ramalho, Luís M. S. Loura, Maria J. Moreno
Format: Article
Language:English
Published: MDPI AG 2023-07-01
Series:Molecules
Subjects:
biomembranes
cationic amphiphiles
fluorescent probe
membrane partition
molecular dynamics simulations
POPC
Online Access:https://www.mdpi.com/1420-3049/28/15/5640

Internet

https://www.mdpi.com/1420-3049/28/15/5640

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