SARS-CoV-2 Infection of Airway Epithelium Triggers Pulmonary Endothelial Cell Activation and Senescence Associated with Type I IFN Production

SARS-CoV-2 Infection of Airway Epithelium Triggers Pulmonary Endothelial Cell Activation and Senescence Associated with Type I IFN Production

Airway epithelial cells represent the main target of SARS-CoV-2 replication but several pieces of evidence suggest that endothelial cells (ECs), lining pulmonary blood vessels, are key players in lung injury in COVID-19 patients. Although in vivo evidence of SARS-CoV-2 affecting the vascular endothe...

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Bibliographic Details
Main Authors: Veronica Bordoni, Davide Mariotti, Giulia Matusali, Francesca Colavita, Eleonora Cimini, Giuseppe Ippolito, Chiara Agrati
Format: Article
Language:English
Published: MDPI AG 2022-09-01
Series:Cells
Subjects:
COVID-19
endothelial cells
airway epithelium
senescence
IFN-β
Online Access:https://www.mdpi.com/2073-4409/11/18/2912

Internet

https://www.mdpi.com/2073-4409/11/18/2912

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