A Critical Role of Glutamine and Asparagine γ-Nitrogen in Nucleotide Biosynthesis in Cancer Cells Hijacked by an Oncogenic Virus

A Critical Role of Glutamine and Asparagine γ-Nitrogen in Nucleotide Biosynthesis in Cancer Cells Hijacked by an Oncogenic Virus

ABSTRACT While glutamine is a nonessential amino acid that can be synthesized from glucose, some cancer cells primarily depend on glutamine for their growth, proliferation, and survival. Numerous types of cancer also depend on asparagine for cell proliferation. The underlying mechanisms of the gluta...

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Bibliographic Details
Main Authors: Ying Zhu, Tingting Li, Suzane Ramos da Silva, Jae-Jin Lee, Chun Lu, Hyungjin Eoh, Jae U. Jung, Shou-Jiang Gao
Format: Article
Language:English
Published: American Society for Microbiology 2017-09-01
Series:mBio
Subjects:
γ-nitrogen
asparagine
cancer
glutamine
KSHV
Online Access:https://journals.asm.org/doi/10.1128/mBio.01179-17

Internet

https://journals.asm.org/doi/10.1128/mBio.01179-17

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