Prestimulation of CD2 confers resistance to HIV-1 latent infection in blood resting CD4 T cells

Prestimulation of CD2 confers resistance to HIV-1 latent infection in blood resting CD4 T cells

Summary: HIV-1 infects blood CD4 T cells through the use of CD4 and CXCR4 or CCR5 receptors, which can be targeted through blocking viral binding to CD4/CXCR4/CCR5 or virus-cell fusion. Here we describe a novel mechanism by which HIV-1 nuclear entry can also be blocked through targeting a non-entry...

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Bibliographic Details
Main Authors: Sijia He, Jia Guo, Yajing Fu, Mark Spear, Chaolong Qin, Shuai Fu, Zongqiang Cui, Wenwen Jin, Xuehua Xu, Wanjun Chen, Hong Shang, Yuntao Wu
Format: Article
Language:English
Published: Elsevier 2021-11-01
Series:iScience
Subjects:
Immune response
Immunology
Virology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004221012748

Internet

http://www.sciencedirect.com/science/article/pii/S2589004221012748

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