CD137 agonist induces gastric cancer cell apoptosis by enhancing the functions of CD8+ T cells via NF-κB signaling

CD137 agonist induces gastric cancer cell apoptosis by enhancing the functions of CD8+ T cells via NF-κB signaling

Abstract Background CD137 is a target for tumor immunotherapy. However, the role of CD137 in gastric cancer (GC), especially in inducing GC cell apoptosis, has not been studied. Methods Foxp3+ and CD8+ T cells in GCs were investigated using immunohistochemistry (IHC). CD137 expression in GCs was det...

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Bibliographic Details
Main Authors: Ben-Shun Hu, Tian Tang, Jun-Li Jia, Bi-Chen Xie, Tie-Long Wu, Ying-Yue Sheng, Yu-Zheng Xue, Hua-Min Tang
Format: Article
Language:English
Published: BMC 2020-10-01
Series:Cancer Cell International
Subjects:
CD137
Gastric cancer
CD8+ T cells
Immune microenvironment
Immune checkpoint
Online Access:http://link.springer.com/article/10.1186/s12935-020-01605-0

Internet

http://link.springer.com/article/10.1186/s12935-020-01605-0

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