DNA Demethylation Switches Oncogenic ΔNp63 to Tumor Suppressive TAp63 in Squamous Cell Carcinoma

DNA Demethylation Switches Oncogenic ΔNp63 to Tumor Suppressive TAp63 in Squamous Cell Carcinoma

The TP63 gene encodes two major protein variants; TAp63 contains a p53-like transcription domain and consequently has tumor suppressor activities whereas ΔNp63 lacks this domain and acts as an oncogene. The two variants show distinct expression patterns in normal tissues and tumors, with lymphocytes...

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Bibliographic Details
Main Authors: Zuzana Pokorna, Vaclav Hrabal, Vlastimil Tichy, Borivoj Vojtesek, Philip J. Coates
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-07-01
Series:Frontiers in Oncology
Subjects:
ΔNp63
TAp63
alternative promoter usage
squamous cell carcinoma
keratinocytes
DNA methylation
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.924354/full

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https://www.frontiersin.org/articles/10.3389/fonc.2022.924354/full

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