H3K27 acetylation and gene expression analysis reveals differences in placental chromatin activity in fetal growth restriction

H3K27 acetylation and gene expression analysis reveals differences in placental chromatin activity in fetal growth restriction

Abstract Background Posttranslational modification of histone tails such as histone 3 lysine 27 acetylation (H3K27ac) is tightly coupled to epigenetic regulation of gene expression. To explore whether this is involved in placenta pathology, we probed genome-wide H3K27ac occupancy by chromatin immuno...

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Bibliographic Details
Main Authors: N. D. Paauw, A. T. Lely, J. A. Joles, A. Franx, P. G. Nikkels, M. Mokry, B. B. van Rijn
Format: Article
Language:English
Published: BMC 2018-06-01
Series:Clinical Epigenetics
Subjects:
ChIP-seq
Growth restriction
H3K27ac
Epigenetics
Histone acetylation
Placenta
Online Access:http://link.springer.com/article/10.1186/s13148-018-0508-x

Internet

http://link.springer.com/article/10.1186/s13148-018-0508-x

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