Modulation of the 5-Lipoxygenase Pathway by Chalcogen-Containing Inhibitors of Leukotriene A<sub>4</sub> Hydrolase

Modulation of the 5-Lipoxygenase Pathway by Chalcogen-Containing Inhibitors of Leukotriene A<sub>4</sub> Hydrolase

The 5-lipoxygenase (5-LOX) pathway gives rise to bioactive inflammatory lipid mediators, such as leukotrienes (LTs). 5-LOX carries out the oxygenation of arachidonic acid to the 5-hydroperoxy derivative and then to the leukotriene A<sub>4</sub> epoxide which is converted to a chemotactic...

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Bibliographic Details
Main Authors: Tarvi Teder, Stefanie König, Rajkumar Singh, Bengt Samuelsson, Oliver Werz, Ulrike Garscha, Jesper Z. Haeggström
Format: Article
Language:English
Published: MDPI AG 2023-04-01
Series:International Journal of Molecular Sciences
Subjects:
5-lipoxygenase
aminopeptidase
inflammation
leukotriene A<sub>4</sub> hydrolase
Online Access:https://www.mdpi.com/1422-0067/24/8/7539

Internet

https://www.mdpi.com/1422-0067/24/8/7539

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