Complement-Mediated Neutralisation Identified in Ebola Virus Disease Survivor Plasma: Implications for Protection and Pathogenesis

Complement-Mediated Neutralisation Identified in Ebola Virus Disease Survivor Plasma: Implications for Protection and Pathogenesis

The 2013–2016 Ebola virus (EBOV) epidemic in West Africa was unprecedented in case numbers and fatalities, and sporadic outbreaks continue to arise. Antibodies to the EBOV glycoprotein (GP) are strongly associated with survival and their use in immunotherapy is often initially based on their perform...

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Bibliographic Details
Main Authors: Jack Mellors, Tom Tipton, Sarah Katharina Fehling, Joseph Akoi Bore, Fara Raymond Koundouno, Yper Hall, Jacob Hudson, Frances Alexander, Stephanie Longet, Stephen Taylor, Andrew Gorringe, N’Faly Magassouba, Mandy Kader Konde, Julian Hiscox, Thomas Strecker, Miles Carroll
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-04-01
Series:Frontiers in Immunology
Subjects:
complement system
immunology
virology
neutralisation
ebola virus
antibodies
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.857481/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.857481/full

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