Design, Synthesis and Structure-Activity Relationship Studies of Meridianin Derivatives as Novel JAK/STAT3 Signaling Inhibitors

Design, Synthesis and Structure-Activity Relationship Studies of Meridianin Derivatives as Novel JAK/STAT3 Signaling Inhibitors

Hyperactivation of Janus kinase (JAK)/signal transducer and activator of transcription 3 (STAT3) signaling is an attractive therapeutic target for tumor therapy. Herein, forty-eight novel meridianin derivatives were designed and synthesized, and their antitumor activity was evaluated in vitro both f...

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Bibliographic Details
Main Authors: Jian-Qiang Zhang, Rui Li, Xue-Yang Dong, Na He, Rui-Juan Yin, Meng-Ke Yang, Jie-Yu Liu, Ri-Lei Yu, Chen-Yang Zhao, Tao Jiang
Format: Article
Language:English
Published: MDPI AG 2022-02-01
Series:International Journal of Molecular Sciences
Subjects:
JAK/STAT3 signaling pathway
meridianin derivatives
isothiouronium
antitumor activity
Online Access:https://www.mdpi.com/1422-0067/23/4/2199

Internet

https://www.mdpi.com/1422-0067/23/4/2199

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