FTY720 induces apoptosis of M2 subtype acute myeloid leukemia cells by targeting sphingolipid metabolism and increasing endogenous ceramide levels.

FTY720 induces apoptosis of M2 subtype acute myeloid leukemia cells by targeting sphingolipid metabolism and increasing endogenous ceramide levels.

The M2 subtype Acute Myeloid Leukemia (AML-M2) with t(8;21) represents an unmet challenge because of poor clinical outcomes in a sizable portion of patients. In this study,we report that FTY720 (Fingolimod), a sphingosine analogue and an FDA approved drug for treating of multiple sclerosis, shows an...

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Bibliographic Details
Main Authors: Limin Chen, Liu-Fei Luo, Junyan Lu, Lianchun Li, Yuan-Fang Liu, Jiang Wang, Hong Liu, Heng Song, Hualiang Jiang, Sai-Juan Chen, Cheng Luo, Keqin Kathy Li
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4106898?pdf=render

Internet

http://europepmc.org/articles/PMC4106898?pdf=render

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