The study of antiviral drugs targeting SARS-CoV-2 nucleocapsid and spike proteins through large-scale compound repurposing

Contributing to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) clinical treatment, a drug library encompassing approximately 3,142 clinical-stage or FDA-approved small molecules is profiled to identify the candidate therapeutic inhibitors targeting nucleocapsid protein (N) and spike pr...

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Bibliographic Details
Main Authors: Xuqiao Hu, Zhenru Zhou, Fei Li, Yang Xiao, Zhaoyang Wang, Jinfeng Xu, Fajin Dong, Hairong Zheng, Rongmin Yu
Format: Article
Language:English
Published: Elsevier 2021-03-01
Series:Heliyon
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844021004928