In Vivo Treatment with Insulin-like Growth Factor 1 Reduces CCR5 Expression on Vaccine-Induced Activated CD4<sup>+</sup> T-Cells

In Vivo Treatment with Insulin-like Growth Factor 1 Reduces CCR5 Expression on Vaccine-Induced Activated CD4<sup>+</sup> T-Cells

At the heart of the DNA/ALVAC/gp120/alum vaccine’s efficacy in the absence of neutralizing antibodies is a delicate balance of pro- and anti-inflammatory immune responses that effectively decreases the risk of SIV<sub>mac251</sub> acquisition in macaques. Vaccine efficacy is linked to an...

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Bibliographic Details
Main Authors: Massimiliano Bissa, Veronica Galli, Luca Schifanella, Monica Vaccari, Mohammad Arif Rahman, Giacomo Gorini, Nicolò Binello, Sarkis Sarkis, Anna Gutowska, Isabela Silva de Castro, Melvin N. Doster, Ramona Moles, Guido Ferrari, Xiaoying Shen, Georgia D. Tomaras, David C. Montefiori, Kombo F. N’guessan, Dominic Paquin-Proulx, Pamela A. Kozlowski, David J. Venzon, Hyoyoung Choo-Wosoba, Matthew W. Breed, Joshua Kramer, Genoveffa Franchini
Format: Article
Language:English
Published: MDPI AG 2023-10-01
Series:Vaccines
Subjects:
IGF-1
HIV
SIV
insulin-like growth factor
CCR5
CD4
Online Access:https://www.mdpi.com/2076-393X/11/11/1662

Internet

https://www.mdpi.com/2076-393X/11/11/1662

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