CircPOFUT1 fosters colorectal cancer metastasis and chemoresistance via decoying miR-653-5p/E2F7/WDR66 axis and stabilizing BMI1

CircPOFUT1 fosters colorectal cancer metastasis and chemoresistance via decoying miR-653-5p/E2F7/WDR66 axis and stabilizing BMI1

Summary: CircRNAs are implicated in colorectal cancer (CRC) development and progression. Protein O-fucosyltransferase 1 (POFUT1) plays an oncogenic role via activating Notch1 signaling in CRC. However, the roles of circPOFUT1, which is originated from POFUT1, have not been investigated. Our study sh...

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Bibliographic Details
Main Authors: Fei Long, Buning Tian, Liang Li, Min Ma, Zhijian Chen, Guojiang Tan, Ning Yin, Chonglei Zhong, Bowen Yu, Yihang Guo, Miao Chen, Gui Hu
Format: Article
Language:English
Published: Elsevier 2024-01-01
Series:iScience
Subjects:
Cancer
Cell biology
Molecular biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004223028067

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http://www.sciencedirect.com/science/article/pii/S2589004223028067

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