Regional nigral neuromelanin degeneration in asymptomatic leucine-rich repeat kinase 2 gene carrier using MRI

Regional nigral neuromelanin degeneration in asymptomatic leucine-rich repeat kinase 2 gene carrier using MRI

Abstract Asymptomatic Leucine-Rich Repeat Kinase 2 Gene (LRRK2) carriers are at risk for developing Parkinson's disease (PD). We studied presymptomatic substantia nigra pars compacta (SNc) regional neurodegeneration in asymptomatic LRRK2 carriers compared to idiopathic PD patients using neurome...

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Bibliographic Details
Main Authors: Linlin Gao, Rahul Gaurav, Pia Ziegner, Jinghong Ma, Junyan Sun, Jie Chen, Jiliang Fang, Yangyang Fan, Yan Bao, Dongling Zhang, Piu Chan, Qi Yang, Zhaoyang Fan, Stéphane Lehéricy, Tao Wu
Format: Article
Language:English
Published: Nature Portfolio 2024-05-01
Series:Scientific Reports
Subjects:
Asymptomatic leucine-rich repeat kinase 2 (LRRK2) gene carrier
Parkinson’s disease (PD)
MRI
Neuromelanin
Substantia nigra (SN)
Online Access:https://doi.org/10.1038/s41598-024-59074-8

Internet

https://doi.org/10.1038/s41598-024-59074-8

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