Tim4 recognizes carbon nanotubes and mediates phagocytosis leading to granuloma formation

Tim4 recognizes carbon nanotubes and mediates phagocytosis leading to granuloma formation

Summary: Macrophage recognition and phagocytosis of crystals is critical for the associated fibrosis and cancer. Of note, multi-walled carbon nanotubes (MWCNTs), the highly representative products of nanotechnology, induce macrophage NLRP3 inflammasome activation and cause asbestosis-like pathogenes...

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Bibliographic Details
Main Authors: Satoshi Omori, Misato Tsugita, Yasuto Hoshikawa, Masanobu Morita, Fumiya Ito, Shin-Ichiro Yamaguchi, Qilin Xie, Osamu Noyori, Tomoya Yamaguchi, Ayato Takada, Tatsuya Saitoh, Shinya Toyokuni, Hisaya Akiba, Shigekazu Nagata, Kengo Kinoshita, Masafumi Nakayama
Format: Article
Language:English
Published: Elsevier 2021-02-01
Series:Cell Reports
Subjects:
Tim-4
Tim-1
Caspase-1
IL-1β
nanomaterials
molecular dynamics simulation
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124721000474

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http://www.sciencedirect.com/science/article/pii/S2211124721000474

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