Neuroprotective Effects of Dexmedetomidine against Thapsigargin-induced ER-stress via Activity of α<sub>2</sub>-adrenoceptors and Imidazoline Receptors

Neuroprotective Effects of Dexmedetomidine against Thapsigargin-induced ER-stress via Activity of α<sub>2</sub>-adrenoceptors and Imidazoline Receptors

Dexmedetomidine is a potent and highly selective α<sub>2</sub>-adrenoceptor agonist with sedative, analgesic, and sympatholytic properties, though it also exhibits some affinity for imidazoline binding sites. In addition to its sedative effects, dexmedetomidine exerts neuroprotective eff...

Full description

Bibliographic Details
Main Authors: Manami Inagaki, Masayuki Somei, Tatsunori Oguchi, Ran Ono, Sachie Fukutaka, Ikumi Matsuoka, Mayumi Tsuji, Katsuji Oguchi
Format: Article
Language:English
Published: AIMS Press 2016-07-01
Series:AIMS Neuroscience
Subjects:
dexmedetomidine
α<sub>2</sub>-agonist
imidazoline receptor
ER-stress-mediated apoptosis
ischemia
neurodegeneration
Online Access:http://www.aimspress.com/neuroscience/article/860/fulltext.html

Internet

http://www.aimspress.com/neuroscience/article/860/fulltext.html

Similar Items