Neuroprotective Effects of Dexmedetomidine against Thapsigargin-induced ER-stress via Activity of α<sub>2</sub>-adrenoceptors and Imidazoline Receptors

Neuroprotective Effects of Dexmedetomidine against Thapsigargin-induced ER-stress via Activity of α<sub>2</sub>-adrenoceptors and Imidazoline Receptors

Dexmedetomidine is a potent and highly selective α<sub>2</sub>-adrenoceptor agonist with sedative, analgesic, and sympatholytic properties, though it also exhibits some affinity for imidazoline binding sites. In addition to its sedative effects, dexmedetomidine exerts neuroprotective eff...

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Bibliographic Details
Main Authors: Manami Inagaki, Masayuki Somei, Tatsunori Oguchi, Ran Ono, Sachie Fukutaka, Ikumi Matsuoka, Mayumi Tsuji, Katsuji Oguchi
Format: Article
Language:English
Published: AIMS Press 2016-07-01
Series:AIMS Neuroscience
Subjects:
dexmedetomidine
α<sub>2</sub>-agonist
imidazoline receptor
ER-stress-mediated apoptosis
ischemia
neurodegeneration
Online Access:http://www.aimspress.com/neuroscience/article/860/fulltext.html

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