Current Landscape and Potential Challenges of Immune Checkpoint Inhibitors in Microsatellite Stable Metastatic Colorectal Carcinoma

Current Landscape and Potential Challenges of Immune Checkpoint Inhibitors in Microsatellite Stable Metastatic Colorectal Carcinoma

Colorectal cancer (CRC) is the third most frequent cancer and the second most common cause of cancer-related death in Europe. High microsatellite instability (MSI-H) due to a deficient DNA mismatch repair (dMMR) system can be found in 5% of metastatic CRC (mCRC) and has been established as a biomark...

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Bibliographic Details
Main Authors: María San-Román-Gil, Javier Torres-Jiménez, Javier Pozas, Jorge Esteban-Villarrubia, Víctor Albarrán-Fernández, Pablo Álvarez-Ballesteros, Jesús Chamorro-Pérez, Diana Rosero-Rodríguez, Inmaculada Orejana-Martín, Íñigo Martínez-Delfrade, Pablo Reguera-Puertas, Raquel Fuentes-Mateos, Reyes Ferreiro-Monteagudo
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:Cancers
Subjects:
metastatic colorectal carcinoma (mCRC)
pMMR
MSS
immune checkpoint inhibitors (ICI)
biomarkers
POLE/POLD1
Online Access:https://www.mdpi.com/2072-6694/15/3/863

Internet

https://www.mdpi.com/2072-6694/15/3/863

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