The interplay of lung surfactant proteins and lipids assimilates the macrophage clearance of nanoparticles.

The peripheral lungs are a potential entrance portal for nanoparticles into the human body due to their large surface area. The fact that nanoparticles can be deposited in the alveolar region of the lungs is of interest for pulmonary drug delivery strategies and is of equal importance for toxicologi...

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Bibliographic Details
Main Authors: Christian A Ruge, Ulrich F Schaefer, Jennifer Herrmann, Julian Kirch, Olga Cañadas, Mercedes Echaide, Jesús Pérez-Gil, Cristina Casals, Rolf Müller, Claus-Michael Lehr
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3393659?pdf=render