ANXA1 Contained in EVs Regulates Macrophage Polarization in Tumor Microenvironment and Promotes Pancreatic Cancer Progression and Metastasis

ANXA1 Contained in EVs Regulates Macrophage Polarization in Tumor Microenvironment and Promotes Pancreatic Cancer Progression and Metastasis

The tumor microenvironment (TME) is a dynamic system where nontumor and cancer cells intercommunicate through soluble factors and extracellular vesicles (EVs). The TME in pancreatic cancer (PC) is critical for its aggressiveness and the annexin A1 (ANXA1) has been identified as one of the oncogenic...

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Bibliographic Details
Main Authors: Nunzia Novizio, Raffaella Belvedere, Emanuela Pessolano, Silvana Morello, Alessandra Tosco, Pietro Campiglia, Amelia Filippelli, Antonello Petrella
Format: Article
Language:English
Published: MDPI AG 2021-10-01
Series:International Journal of Molecular Sciences
Subjects:
annexin A1
macrophage polarization
pancreatic cancer
extracellular vesicles
tumor microenvironment
Online Access:https://www.mdpi.com/1422-0067/22/20/11018

Internet

https://www.mdpi.com/1422-0067/22/20/11018

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