8-Aminoguanine and its actions in the metabolic syndrome

8-Aminoguanine and its actions in the metabolic syndrome

Abstract The metabolic syndrome is characterized by obesity, insulin resistance, dyslipidemia and hypertension and predisposes to cardiorenal injury. Here, we tested our hypothesis that 8-aminoguanine, an endogenous purine, exerts beneficial effects in Zucker Diabetic-Sprague Dawley (ZDSD) rats, a p...

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Bibliographic Details
Main Authors: Edwin K. Jackson, Delbert G. Gillespie, Zaichuan Mi, Lori A. Birder, Stevan P. Tofovic
Format: Article
Language:English
Published: Nature Portfolio 2024-09-01
Series:Scientific Reports
Subjects:
8-Aminoguanine
Metabolic syndrome
Inosine
Hypoxanthine
Interleukin-1β
Angiotensin II
Online Access:https://doi.org/10.1038/s41598-024-73159-4

Internet

https://doi.org/10.1038/s41598-024-73159-4

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