Druggable Pockets at the RNA Interface Region of Influenza A Virus NS1 Protein Are Conserved across Sequence Variants from Distinct Subtypes

Druggable Pockets at the RNA Interface Region of Influenza A Virus NS1 Protein Are Conserved across Sequence Variants from Distinct Subtypes

Influenza A viruses still represent a major health issue, for both humans and animals. One of the main viral proteins of interest to target is the NS1 protein, which counters the host immune response and promotes viral replication. NS1 is a homodimer composed of a dimeric RNA-binding domain (RBD), w...

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Bibliographic Details
Main Authors: Sarah Naceri, Daniel Marc, Rachel Blot, Delphine Flatters, Anne-Claude Camproux
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:Biomolecules
Subjects:
binding site
influenza A virus
non-structural protein 1
groove-pocket
drug design
structural polymorphism
Online Access:https://www.mdpi.com/2218-273X/13/1/64

Internet

https://www.mdpi.com/2218-273X/13/1/64

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