Icariin Inhibits Overexpression and Aggregation of α-Synuclein in A53T α-Synuclein Transgenic Mice by Regulating Parkin and PLK2

Icariin Inhibits Overexpression and Aggregation of α-Synuclein in A53T α-Synuclein Transgenic Mice by Regulating Parkin and PLK2

Background: Synucleinopathies, which are major pathological features of Parkinson’s disease (PD), are characterized by misfolded aggregates of α-synuclein in the peripheral and central nervous system. Icariin (ICA) is the main active component of Epimedium flavonoids. Our previous study found that I...

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Bibliographic Details
Main Authors: Denglei Ma, Cong Shen, Xu Zhang, Lan Zhang, Lin Li
Format: Article
Language:English
Published: IMR Press 2023-11-01
Series:Journal of Integrative Neuroscience
Subjects:
icariin
synucleinopathy
α-synuclein
motor impairment
parkin
plk2
Online Access:https://www.imrpress.com/journal/JIN/22/6/10.31083/j.jin2206166

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https://www.imrpress.com/journal/JIN/22/6/10.31083/j.jin2206166

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