Imidazo[1,2-c]quinazolines as a novel and potent scaffold of α-glucosidase inhibitors: design, synthesis, biological evaluations, and in silico studies

Imidazo[1,2-c]quinazolines as a novel and potent scaffold of α-glucosidase inhibitors: design, synthesis, biological evaluations, and in silico studies

Abstract α-Glucosidase inhibition is an approved treatment for type 2 diabetes mellitus (T2DM). In an attempt to develop novel anti-α-glucosidase agents, two series of substituted imidazo[1,2-c]quinazolines, namely 6a–c and 11a–o, were synthesized using a simple, straightforward synthetic routes. Th...

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Bibliographic Details
Main Authors: Fariba Peytam, Faezeh sadat Hosseini, Malak Hekmati, Bahareh Bayati, Mahdis Sadeghi Moghadam, Zahra Emamgholipour, Loghman Firoozpour, Somayeh Mojtabavi, Mohammad Ali Faramarzi, Seyed Esmaeil Sadat-Ebrahimi, Maliheh Barazandeh Tehrani, Alireza Foroumadi
Format: Article
Language:English
Published: Nature Portfolio 2023-09-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-023-42549-5

Internet

https://doi.org/10.1038/s41598-023-42549-5

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