M1 polarization enhances the antitumor activity of chimeric antigen receptor macrophages in solid tumors

M1 polarization enhances the antitumor activity of chimeric antigen receptor macrophages in solid tumors

Abstract Background Chimeric antigen receptor macrophage (CAR-M) therapy is a novel cancer immunotherapy approach that integrates CAR structure and macrophage functions. CAR-M therapy has shown unique and impressive antitumor effects in immunotherapy for solid tumors. However, the polarization state...

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Bibliographic Details
Main Authors: Yi Huo, Han Zhang, Longqi Sa, Wenjing Zheng, Yang He, Haohan Lyu, Mengjie Sun, Lingling Zhang, Lequn Shan, Angang Yang, Tao Wang
Format: Article
Language:English
Published: BMC 2023-03-01
Series:Journal of Translational Medicine
Subjects:
Chimeric antigen receptor
Macrophages
CAR-M
M1 polarization
HER2
Cancer immunotherapy
Online Access:https://doi.org/10.1186/s12967-023-04061-2

Internet

https://doi.org/10.1186/s12967-023-04061-2

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