Genetic Manipulation of Human Intestinal Enteroids Demonstrates the Necessity of a Functional Fucosyltransferase 2 Gene for Secretor-Dependent Human Norovirus Infection

Genetic Manipulation of Human Intestinal Enteroids Demonstrates the Necessity of a Functional Fucosyltransferase 2 Gene for Secretor-Dependent Human Norovirus Infection

ABSTRACT Human noroviruses (HuNoVs) are the leading cause of nonbacterial gastroenteritis worldwide. Histo-blood group antigen (HBGA) expression is an important susceptibility factor for HuNoV infection based on controlled human infection models and epidemiologic studies that show an association of...

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Bibliographic Details
Main Authors: Kei Haga, Khalil Ettayebi, Victoria R. Tenge, Umesh C. Karandikar, Miranda A. Lewis, Shih-Ching Lin, Frederick H. Neill, B. Vijayalakshmi Ayyar, Xi-Lei Zeng, Göran Larson, Sasirekha Ramani, Robert L. Atmar, Mary K. Estes
Format: Article
Language:English
Published: American Society for Microbiology 2020-04-01
Series:mBio
Subjects:
fucosyltransferase 2
glycobiology
histo-blood group antigens
isogenic enteroids
isogenic organoids
noroviruses
Online Access:https://journals.asm.org/doi/10.1128/mBio.00251-20

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https://journals.asm.org/doi/10.1128/mBio.00251-20

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