Perimenopausal Effects of Estradiol on Anhedonia and Psychosis Study (PEEPs): study protocol for a neural and molecular mechanistic clinical trial

Perimenopausal Effects of Estradiol on Anhedonia and Psychosis Study (PEEPs): study protocol for a neural and molecular mechanistic clinical trial

Abstract Background The perimenopausal transition is accompanied by psychiatric symptoms in over 10% of women. Symptoms commonly include depressed mood and anhedonia and less commonly include psychosis. Psychiatric symptoms have been linked to the depletion and/or variability of circulating estradio...

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Bibliographic Details
Main Authors: Melissa J. M. Walsh, Kathryn Gibson, Megan Hynd, Tory A. Eisenlohr-Moul, Erin C. Walsh, Lauren Schiff, Fred Jarskog, David Lalush, Gabriel S. Dichter, Crystal E. Schiller
Format: Article
Language:English
Published: BMC 2023-02-01
Series:Trials
Subjects:
Menopause
Depression
Anhedonia
Psychosis
Estrogen
Rewards
Online Access:https://doi.org/10.1186/s13063-023-07166-7

Internet

https://doi.org/10.1186/s13063-023-07166-7

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