Electrical stimulation of the ventral tegmental area restores consciousness from sevoflurane-, dexmedetomidine-, and fentanyl-induced unconsciousness in rats

Electrical stimulation of the ventral tegmental area restores consciousness from sevoflurane-, dexmedetomidine-, and fentanyl-induced unconsciousness in rats

Background: Dopaminergic neurons in the ventral tegmental area (VTA) are crucially involved in regulating arousal, making them a potential target for reversing general anesthesia. Electrical deep brain stimulation (DBS) of the VTA restores consciousness in animals anesthetized with drugs that primar...

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Bibliographic Details
Main Authors: Kathleen F. Vincent, Edlyn R. Zhang, Angel J. Cho, Risako Kato-Miyabe, Olivia G. Mallari, Olivia A. Moody, David P. Obert, Gwi H. Park, Ken Solt
Format: Article
Language:English
Published: Elsevier 2024-05-01
Series:Brain Stimulation
Subjects:
Ventral tegmental area
Dexmedetomidine
Fentanyl
Ketamine
General anesthesia
Dopamine D1 receptor
Online Access:http://www.sciencedirect.com/science/article/pii/S1935861X24000949

Internet

http://www.sciencedirect.com/science/article/pii/S1935861X24000949

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