PTEN Controls the DNA Replication Process through MCM2 in Response to Replicative Stress

PTEN Controls the DNA Replication Process through MCM2 in Response to Replicative Stress

PTEN is a tumor suppressor frequently mutated in human cancers. PTEN inhibits the phosphatidylinositol 3-kinase (PI3K)-AKT cascade, and nuclear PTEN guards the genome by multiple mechanisms. Here, we report that PTEN physically associates with the minichromosome maintenance complex component 2 (MCM2...

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Bibliographic Details
Main Authors: Jiawen Feng, Jing Liang, Jiaju Li, Yunqiao Li, Hui Liang, Xuyang Zhao, Michael A. McNutt, Yuxin Yin
Format: Article
Language:English
Published: Elsevier 2015-11-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124715011705

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http://www.sciencedirect.com/science/article/pii/S2211124715011705

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